pH-responsive mechanised nanoparticles gated by semirotaxanes

Chem Commun (Camb). 2009 Sep 28:(36):5371-3. doi: 10.1039/b910431c. Epub 2009 Aug 18.

Abstract

A [2]pseudorotaxane-based mechanised nanoparticle system, which operates within an aqueous acidic environment, has been prepared and characterised; this integrated system affords both water-soluble stalk and ring components in an effort to improve the biocompatibility of these promising new drug delivery vehicles.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biocompatible Materials / chemistry
  • Bridged-Ring Compounds / chemistry
  • Drug Delivery Systems / methods*
  • Hydrogen-Ion Concentration
  • Imidazoles / chemistry
  • Macrocyclic Compounds / chemistry
  • Magnetic Resonance Spectroscopy
  • Nanoparticles / chemistry*
  • Rhodamines / chemistry
  • Rotaxanes / chemistry*
  • Silicon Dioxide / chemistry
  • Spectrometry, Fluorescence
  • Viologens / chemistry

Substances

  • Biocompatible Materials
  • Bridged-Ring Compounds
  • Imidazoles
  • Macrocyclic Compounds
  • Rhodamines
  • Rotaxanes
  • Viologens
  • Silicon Dioxide
  • cucurbit(6)uril
  • rhodamine B