Abstract
Evaluation of: Sui J, Hwang WC, Perez S et al. Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat. Struct. Mol. Biol. 16(3), 265-273 (2009). The continuous antigenic drifts and occasional antigenic shifts enable human influenza viruses to escape the human immune system. Moreover, the frequent occurrence of human H5N1-infected cases and the recent emergency of a novel swine-like human H1N1 influenza virus further reiterate the risk of the introduction of a new pandemic strain to humans through in toto transfer of an animal influenza virus. The discovery of neutralizing antibodies that are broadly reactive with multiple influenza subtypes is therefore extremely important for the influenza pandemic preparedness, for use either for therapeutic purposes or as the basis of vaccine development. Here, we review some of the recent developments in this area.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibodies, Monoclonal / chemistry
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Antibodies, Monoclonal / immunology*
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Antibodies, Viral / chemistry
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Antibodies, Viral / immunology
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Cross Reactions
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Epitopes / immunology*
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Hemagglutinin Glycoproteins, Influenza Virus* / chemistry
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Hemagglutinin Glycoproteins, Influenza Virus* / immunology
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Humans
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Influenza A Virus, H1N1 Subtype / immunology
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Influenza A Virus, H5N1 Subtype / immunology
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Influenza A virus / classification
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Influenza A virus / immunology*
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Influenza, Human* / immunology
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Influenza, Human* / prevention & control
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Influenza, Human* / virology
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Neutralization Tests
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Orthomyxoviridae Infections* / immunology
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Orthomyxoviridae Infections* / prevention & control
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Orthomyxoviridae Infections* / virology
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Peptide Library
Substances
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Antibodies, Monoclonal
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Antibodies, Viral
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Epitopes
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Hemagglutinin Glycoproteins, Influenza Virus
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Peptide Library