Discovery of swine as a host for the Reston ebolavirus

Roger W Barrette; Samia A Metwally; Jessica M Rowland; Lizhe Xu; Sherif R Zaki; Stuart T Nichol; Pierre E Rollin; Jonathan S Towner; Wun-Ju Shieh; Brigid Batten; Tara K Sealy; Consuelo Carrillo; Karen E Moran; Alexa J Bracht; Gregory A Mayr; Magdalena Sirios-Cruz; Davinio P Catbagan; Elizabeth A Lautner; Thomas G Ksiazek; William R White; Michael T McIntosh

doi:10.1126/science.1172705

Discovery of swine as a host for the Reston ebolavirus

Science. 2009 Jul 10;325(5937):204-6. doi: 10.1126/science.1172705.

Affiliation

¹ Foreign Animal Disease Diagnostic Laboratory, National Veterinary Services Laboratories, Animal and Plant Health Inspection Services, United States Department of Agriculture, Plum Island Animal Disease Center, New York, NY 11944, USA.

PMID: 19590002
DOI: 10.1126/science.1172705

Abstract

Since the discovery of the Marburg and Ebola species of filovirus, seemingly random, sporadic fatal outbreaks of disease in humans and nonhuman primates have given impetus to identification of host tropisms and potential reservoirs. Domestic swine in the Philippines, experiencing unusually severe outbreaks of porcine reproductive and respiratory disease syndrome, have now been discovered to host Reston ebolavirus (REBOV). Although REBOV is the only member of Filoviridae that has not been associated with disease in humans, its emergence in the human food chain is of concern. REBOV isolates were found to be more divergent from each other than from the original virus isolated in 1989, indicating polyphyletic origins and that REBOV has been circulating since, and possibly before, the initial discovery of REBOV in monkeys.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Antibodies, Viral / blood
Disease Outbreaks / veterinary
Disease Reservoirs
Ebolavirus / classification
Ebolavirus / genetics
Ebolavirus / immunology
Ebolavirus / isolation & purification*
Filoviridae Infections / complications
Filoviridae Infections / epidemiology
Filoviridae Infections / veterinary*
Filoviridae Infections / virology
Hemorrhagic Fever, Ebola / epidemiology
Hemorrhagic Fever, Ebola / veterinary
Hemorrhagic Fever, Ebola / virology
Humans
Molecular Sequence Data
Philippines / epidemiology
Phylogeny
Porcine Reproductive and Respiratory Syndrome / epidemiology
Porcine Reproductive and Respiratory Syndrome / virology*
Porcine respiratory and reproductive syndrome virus / classification
Porcine respiratory and reproductive syndrome virus / genetics
Porcine respiratory and reproductive syndrome virus / isolation & purification*
Sus scrofa
Swine Diseases / epidemiology
Swine Diseases / virology*

Substances

Antibodies, Viral

Associated data

GENBANK/FJ621583
GENBANK/FJ621584
GENBANK/FJ621585
GEO/GSE15687