The scope of homelessness among children is broad and growing, and its affect on physical and mental health is extensive. It may seem daunting for individual providers to make an impact on the challenges faced by these most vulnerable of patients. However, healthcare providers who care for homeless children can improve more than just their physical health by understanding barriers specific to this population, and addressing them through minor changes in standard practice; education of self, staff, and colleagues; and advocacy. By collaborating with parents and local agencies, clinicians can make tangible progress in improving the health of their homeless patients and can provide parents with the information and support they need to prioritize a child's health needs appropriately. Ultimately, providers should strive to make their practices a true medical home, as it may be the only home a child knows.