Hepatitis B virus genotypes: natural history and implications for treatment

Expert Rev Gastroenterol Hepatol. 2007 Dec;1(2):321-8. doi: 10.1586/17474124.1.2.321.

Abstract

There are eight different genotypes named A-H. Genotypes have distinct geographic distribution in different regions of the world. There exists a difference in the disease profile between different genotypes. Genotype A compared with D, and B compared with C have earlier hepatitis B e-antigen seroconversion and less severe liver disease. However, genotypes are closely linked with core promoter and precore mutations. This may have a confounding effect on the association of genotypes with disease progression. Patients with genotype A compared with D and B compared with C have a better treatment response to IFN-alpha. However, there are no differences in the treatment response and rate of emergence of drug-resistant hepatitis B virus between different genotypes to nucleoside/nucleotide analog therapy.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / therapeutic use*
  • Genotype
  • Hepatitis B / drug therapy*
  • Hepatitis B / virology*
  • Hepatitis B virus / drug effects*
  • Hepatitis B virus / genetics*
  • Humans

Substances

  • Antiviral Agents