Myelodysplastic syndrome and acquired factor VIII inhibitor with severe subcutaneous haemorrhage

Acta Haematol. 1991;85(4):206-8. doi: 10.1159/000204894.

Abstract

A case of acquired haemophilia A presenting with extensive spontaneous bruising and anaemia is reported. The anaemia was due to myelodysplastic syndrome (FAB: refractory anaemia with ringed sideroblasts). A factor-VII:C-specific inhibitor was also found. Prednisone and pyridoxine were given, and the inhibitor became undetectable after 4 weeks of therapy, but the abnormal ringed sideroblasts still persisted on repeated bone marrow biopsy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anemia, Sideroblastic / etiology
  • Anemia, Sideroblastic / pathology
  • Bone Marrow / pathology
  • Factor VIII / antagonists & inhibitors*
  • Female
  • Hemophilia A / complications*
  • Hemophilia A / drug therapy
  • Hemorrhage / etiology*
  • Humans
  • Myelodysplastic Syndromes / complications*
  • Prednisone / therapeutic use
  • Pyridoxine / therapeutic use

Substances

  • Factor VIII
  • Pyridoxine
  • Prednisone