Scaffolding in tissue engineering: general approaches and tissue-specific considerations

Eur Spine J. 2008 Dec;17 Suppl 4(Suppl 4):467-79. doi: 10.1007/s00586-008-0745-3. Epub 2008 Nov 13.

Abstract

Scaffolds represent important components for tissue engineering. However, researchers often encounter an enormous variety of choices when selecting scaffolds for tissue engineering. This paper aims to review the functions of scaffolds and the major scaffolding approaches as important guidelines for selecting scaffolds and discuss the tissue-specific considerations for scaffolding, using intervertebral disc as an example.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biocompatible Materials / therapeutic use*
  • Chondrocytes / cytology
  • Chondrocytes / metabolism
  • Chondrocytes / transplantation
  • Extracellular Matrix / chemistry
  • Extracellular Matrix / metabolism
  • Extracellular Matrix / transplantation
  • Humans
  • Intercellular Signaling Peptides and Proteins / pharmacology
  • Intercellular Signaling Peptides and Proteins / therapeutic use
  • Intervertebral Disc / cytology
  • Intervertebral Disc / metabolism
  • Intervertebral Disc / surgery
  • Intervertebral Disc Displacement / metabolism
  • Intervertebral Disc Displacement / physiopathology
  • Intervertebral Disc Displacement / surgery*
  • Regeneration / drug effects
  • Regeneration / physiology
  • Tissue Engineering / methods*
  • Tissue Engineering / trends*
  • Tissue Scaffolds / standards
  • Tissue Scaffolds / trends*

Substances

  • Biocompatible Materials
  • Intercellular Signaling Peptides and Proteins