Abstract
Necrotizing enterocolitis (NEC), a serious gastrointestinal inflammatory disease, frequently occurs in preterm neonates that fail to adapt to enteral nutrition. A temporal gel-based proteomics study was performed on porcine intestine with NEC lesions induced by enteral formula feeding. Functional assignment of the differentially expressed proteins revealed that important cellular functions, such as the heat shock response, protein processing; and purine, nitrogen, energy metabolism, were possible involved in the early progression of NEC.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Disease Models, Animal
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Electrophoresis, Gel, Two-Dimensional
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Enteral Nutrition / adverse effects*
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Enterocolitis, Necrotizing / diagnosis*
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Enterocolitis, Necrotizing / metabolism*
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Enterocolitis, Necrotizing / veterinary
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Gene Expression Profiling / methods
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Image Processing, Computer-Assisted
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Intestinal Mucosa / metabolism*
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Intestines / pathology
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Mass Spectrometry / methods
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Nutritional Support / adverse effects*
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Premature Birth
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Proteomics / methods*
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Swine
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Time Factors