Abstract
Bloom's syndrome is caused by mutations in the BLM gene. The BLM gene product, BLM helicase, forms a complex with two other proteins, DNA topoisomerase IIIalpha and RMI1. In this issue of Genes & Development, Wang and colleagues (2843-2855) and Meetei and colleagues (2856-2868) report the discovery of a fourth component of this complex called RMI2. RMI2 may be a representative of a new family of OB-fold-containing proteins that are important for complex stabilization and checkpoint response.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Bloom Syndrome / genetics*
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Carrier Proteins / metabolism*
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DNA Helicases / genetics*
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DNA Topoisomerases, Type I / metabolism*
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DNA-Binding Proteins
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Humans
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Mutation / genetics*
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Nuclear Proteins / metabolism*
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Protein Folding
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RecQ Helicases
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Replication Protein A / physiology*
Substances
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Carrier Proteins
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DNA-Binding Proteins
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Nuclear Proteins
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RMI1 protein, human
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RPA1 protein, human
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Replication Protein A
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Bloom syndrome protein
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DNA Helicases
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RecQ Helicases
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DNA Topoisomerases, Type I