More complexity to the Bloom's syndrome complex

Genes Dev. 2008 Oct 15;22(20):2737-42. doi: 10.1101/gad.1732808.

Abstract

Bloom's syndrome is caused by mutations in the BLM gene. The BLM gene product, BLM helicase, forms a complex with two other proteins, DNA topoisomerase IIIalpha and RMI1. In this issue of Genes & Development, Wang and colleagues (2843-2855) and Meetei and colleagues (2856-2868) report the discovery of a fourth component of this complex called RMI2. RMI2 may be a representative of a new family of OB-fold-containing proteins that are important for complex stabilization and checkpoint response.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Bloom Syndrome / genetics*
  • Carrier Proteins / metabolism*
  • DNA Helicases / genetics*
  • DNA Topoisomerases, Type I / metabolism*
  • DNA-Binding Proteins
  • Humans
  • Mutation / genetics*
  • Nuclear Proteins / metabolism*
  • Protein Folding
  • RecQ Helicases
  • Replication Protein A / physiology*

Substances

  • Carrier Proteins
  • DNA-Binding Proteins
  • Nuclear Proteins
  • RMI1 protein, human
  • RPA1 protein, human
  • Replication Protein A
  • Bloom syndrome protein
  • DNA Helicases
  • RecQ Helicases
  • DNA Topoisomerases, Type I