This research explored nursing students' mathematics anxiety, beliefs about mathematics, and mathematics self-efficacy in relation to performance on a medication mathematics test. Results revealed that the participants experienced some mathematics anxiety and had positive beliefs about mathematics and mathematics self-efficacy. Qualitative responses indicated that participants worried about the consequences of failing the medication mathematics test and that practice helped reduce this anxiety. In addition, participants acknowledged the importance of correct dosage calculations for nursing practice. Implications for nursing education are discussed.