Complexes of the copper-containing amine oxidase from Arthrobacter globiformis with the inhibitors benzylhydrazine and tranylcypromine

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 1;64(Pt 7):577-83. doi: 10.1107/S174430910801556X. Epub 2008 Jun 11.

Abstract

Complexes of Arthrobacter globiformis amine oxidase (AGAO) with the inhibitors benzylhydrazine and tranylcypromine (an antidepressant drug) have been refined at 1.86 and 1.65 A resolution, respectively. Both inhibitors form covalent adducts with the TPQ cofactor. A tyrosine residue, proposed to act as a gate to the AGAO active site, is in its open conformation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amine Oxidase (Copper-Containing) / antagonists & inhibitors
  • Amine Oxidase (Copper-Containing) / chemistry*
  • Arthrobacter / drug effects
  • Arthrobacter / enzymology*
  • Bacterial Proteins / antagonists & inhibitors
  • Bacterial Proteins / chemistry*
  • Catalytic Domain / drug effects
  • Crystallography, X-Ray
  • Enzyme Inhibitors / chemistry*
  • Hydrazines / chemistry*
  • Tranylcypromine / chemistry*

Substances

  • Bacterial Proteins
  • Enzyme Inhibitors
  • Hydrazines
  • Tranylcypromine
  • benzylhydrazine
  • Amine Oxidase (Copper-Containing)

Associated data

  • PDB/1W4N
  • PDB/1W5Z