Paradigms have started to shift in the orthodontic world since the introduction of mini-implants in the anchorage armamentarium. For example, miniscrews have allowed the management of wider discrepancies than those treatable by conventional biomechanics because force can be applied directly from the bone-borne anchor unit. Therefore, miniscrews not only free orthodontists from anchorage-demanding cases, but they also enable clinicians to have good control over tooth movement in 3 dimensions. This review will illustrate the versatility of skeletal anchorage provided by mini-implants in the correction of malocclusion, focusing on orthodontic or orthopedic movements in the 3 spatial planes. Adjunctive orthodontic treatments in adult periodontal conditions and treatment for impacted teeth with the aid of miniscrews will also be discussed.