This study examined the outcome of a 2-hour introductory lecture on tobacco and health in improving the knowledge and attitudes of nursing students toward smoking and tobacco control. A group of 78 first-year undergraduate nursing students of a major university in Hong Kong were invited to complete a self-administered questionnaire before and after the lecture. The findings indicated a significant improvement in knowledge of and attitudes about tobacco control. The study suggests that education about smoking and tobacco control should be introduced into the nursing curriculum at an early stage so appropriate knowledge, attitudes, and skills can be subsequently strengthened to prepare students to lead an effective role in delivering tobacco control nursing interventions. Finally, a model of integrating tobacco control content in the undergraduate nursing curriculum was recommended.