GABA effects on neurogenesis: an arsenal of regulation

Sci Signal. 2008 Apr 15;1(15):jc1. doi: 10.1126/stke.115jc1.

Abstract

The well-known inhibitory neurotransmitter GABA is excitatory to immature neurons during development as well as to neural progenitor cells during adult neurogenesis. Recent evidence indicates that GABA plays a role in regulating neurogenesis in various situations. This journal club paper aims to provide a skeleton description of GABA regulation of neurogenesis, describing some of the disparate mechanisms and scenarios in which it is involved.

MeSH terms

  • Animals
  • Neurons / cytology*
  • Neurons / physiology
  • gamma-Aminobutyric Acid / physiology*

Substances

  • gamma-Aminobutyric Acid