Discovery of a drug-like G-quadruplex binding ligand by high-throughput docking

ChemMedChem. 2008 Jun;3(6):881-4. doi: 10.1002/cmdc.200700342.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Binding Sites
  • Binding, Competitive
  • Circular Dichroism
  • Computer Simulation
  • DNA / drug effects
  • Databases as Topic
  • Drug Design*
  • Drug Screening Assays, Antitumor
  • Fluorescence Resonance Energy Transfer
  • G-Quadruplexes / drug effects*
  • Hydrazones / chemistry*
  • Hydrazones / pharmacology*
  • Ligands
  • Models, Molecular
  • Nucleic Acid Conformation / drug effects
  • Pyrazoles / chemistry*
  • Pyrazoles / pharmacology*
  • Structure-Activity Relationship

Substances

  • 1H-pyrazole-3-carboxy-4-methyl-5-phenyl-(1H-indol-3-ylmethylene)hydrazide
  • Antineoplastic Agents
  • Hydrazones
  • Ligands
  • Pyrazoles
  • DNA