Electrospinning of aligned biodegradable polymer fibers and composite fibers for tissue engineering applications

J Nanosci Nanotechnol. 2007 Nov;7(11):3834-40. doi: 10.1166/jnn.2007.051.

Abstract

Fibrous membranes of aligned poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) fibers have been made through electrospinning. A high-speed rotating drum was used as the fiber collector while the electric field was manipulated by using five knife-edged auxiliary electrodes. It was found that a high drum rotating speed of 3000 rpm could lead to a nearly perfect alignment of PHBV fibers during electrospinning. Multilayered fibrous structures with each layer having a different direction of fiber alignment could also be constructed through electrospinning. The electrospun PHBV fibers were further modified by incorporating carbonated hydroxyapatite (HA) nanospheres (up to 20% of HA) in the fibers. The fibrous membranes made of aligned PHBV fibers and made of HA/PHBV composite fibers should be very useful for the tissue engineering of different human body tissues.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorbable Implants*
  • Biocompatible Materials / chemistry*
  • Crystallization / methods*
  • Electrochemistry / methods
  • Macromolecular Substances / chemistry
  • Materials Testing
  • Molecular Conformation
  • Nanostructures / chemistry*
  • Nanostructures / ultrastructure*
  • Nanotechnology / methods
  • Particle Size
  • Polyesters / chemistry*
  • Rotation
  • Surface Properties
  • Tissue Engineering / methods*

Substances

  • Biocompatible Materials
  • Macromolecular Substances
  • Polyesters
  • poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate)