Abstract
Gabapentin is a second generation anticonvulsant that is effective in the treatment of chronic neuropathic pain. It was not, until recently, thought to be useful in acute perioperative conditions. However, a growing body of evidence suggests that perioperative administration is efficacious for postoperative analgesia, preoperative anxiolysis, attenuation of the haemodynamic response to laryngoscopy and intubation, and preventing chronic post-surgical pain, postoperative nausea and vomiting, and delirium. This article reviews the clinical trial data describing the efficacy and safety of gabapentin in the setting of perioperative anaesthetic management.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amines / therapeutic use*
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Analgesics, Non-Narcotic / therapeutic use*
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Anti-Anxiety Agents / therapeutic use
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Blood Pressure / drug effects
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Chronic Disease
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Cyclohexanecarboxylic Acids / therapeutic use*
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Delirium / prevention & control
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Gabapentin
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Heart Rate / drug effects
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Humans
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Pain, Postoperative / prevention & control*
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Postoperative Nausea and Vomiting / prevention & control
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Premedication / methods*
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Randomized Controlled Trials as Topic
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gamma-Aminobutyric Acid / therapeutic use*
Substances
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Amines
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Analgesics, Non-Narcotic
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Anti-Anxiety Agents
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Cyclohexanecarboxylic Acids
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gamma-Aminobutyric Acid
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Gabapentin