Magnetic Resonance Elastography (MRE) is a phase-contrast technique using conventional Magnetic Resonance Imaging system to visualize propagating shear waves and study the stiffness of tissues. Usually, shear vibrations are applied to the surface of tissues by means of mechanical driver at one point. But in femoral artery study, the shear wave generated by the single driver on the surface of thigh cannot reach the femoral artery behind vein because of the blockage from the vein. In this study, the twin drivers set developed in our laboratory is used to overcome the problem. By using twin drivers driven simultaneously, interference shear wave pattern is generated. MR Interference Elastography is using interference shear wave image to study the stiffness of tissues. And, a finite element modeling was used to simulate single and twin driver datasets. The method was applied to in vivo human's femoral artery. And the result demonstrates the feasibility of this method. Further study will be conducted with the twin drivers in more in-vivo studies.