Abstract
A series of bismuth complexes were synthesized and characterized, and most of them exhibited inhibition against the SARS coronavirus helicase ATPase and duplex-unwinding activities at micromolar concentrations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphatases / antagonists & inhibitors
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology*
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Bismuth / chemistry*
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Chromatography, High Pressure Liquid
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Crystallography, X-Ray
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DNA Helicases / antagonists & inhibitors*
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Dimethyl Sulfoxide
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Models, Molecular
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / pharmacology*
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Porphyrins / chemical synthesis
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Porphyrins / pharmacology
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Severe acute respiratory syndrome-related coronavirus / enzymology*
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Zinc / chemistry
Substances
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Antiviral Agents
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Enzyme Inhibitors
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Organometallic Compounds
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Porphyrins
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Adenosine Triphosphatases
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DNA Helicases
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Zinc
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Bismuth
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Dimethyl Sulfoxide