Radiation-induced rhabdomyosarcomatous transformation of a recurrent meningeal haemangiopericytoma

Acta Neurochir (Wien). 2007 Nov;149(11):1163-7; discussion 1167. doi: 10.1007/s00701-007-1289-8. Epub 2007 Oct 1.

Abstract

A 53-year-old woman presented in 1979 with a posterior fossa meningeal haemangiopericytoma (HPC) for which she underwent surgical resection and post-operative radiotherapy. Repeated tumour recurrences occurred 18 years afterwards which were treated with resections and stereotactic radiotherapy. Surgery for tumour recurrence in 2005 revealed features of rhabdomyosarcomatous transformation. To our knowledge, this is the first reported case of rhabdomyosarcomatous transformation within a HPC which was likely to be radiation-induced, and was associated with relentless disease progression more than 20 years after the initial presentation.

Publication types

  • Case Reports

MeSH terms

  • Cell Transformation, Neoplastic / pathology
  • Cell Transformation, Neoplastic / radiation effects*
  • Combined Modality Therapy
  • Cranial Fossa, Posterior / surgery
  • Cranial Irradiation / adverse effects*
  • Disease Progression
  • Fatal Outcome
  • Female
  • Hemangiopericytoma / pathology*
  • Hemangiopericytoma / radiotherapy
  • Hemangiopericytoma / surgery
  • Humans
  • Meningeal Neoplasms / pathology*
  • Meningeal Neoplasms / radiotherapy
  • Meningeal Neoplasms / surgery
  • Middle Aged
  • Neoplasm Recurrence, Local / pathology*
  • Neoplasm Recurrence, Local / surgery
  • Neoplasms, Radiation-Induced / pathology*
  • Radiosurgery
  • Radiotherapy, Adjuvant
  • Reoperation
  • Rhabdomyosarcoma / pathology*
  • Tomography, X-Ray Computed