Marginal analysis of correlated failure time data with informative cluster sizes

Biometrics. 2007 Sep;63(3):663-72. doi: 10.1111/j.1541-0420.2006.00730.x.

Abstract

We consider modeling correlated survival data when cluster sizes may be informative to the outcome of interest based on a within-cluster resampling (WCR) approach and a weighted score function (WSF) method. We derive the large sample properties for the WCR estimators under the Cox proportional hazards model. We establish consistency and asymptotic normality of the regression coefficient estimators, and the weak convergence property of the estimated baseline cumulative hazard function. The WSF method is to incorporate the inverse of cluster sizes as weights in the score function. We conduct simulation studies to assess and compare the finite-sample behaviors of the estimators and apply the proposed methods to a dental study as an illustration.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bias
  • Biometry / methods*
  • Cluster Analysis*
  • Data Interpretation, Statistical*
  • Mortality*
  • Multivariate Analysis*
  • Outcome Assessment, Health Care / methods*
  • Proportional Hazards Models
  • Risk Assessment / methods
  • Risk Factors
  • Sample Size
  • Statistics as Topic*
  • Survival Analysis
  • Survival Rate