Bismuth complexes inhibit the SARS coronavirus

Angew Chem Int Ed Engl. 2007;46(34):6464-8. doi: 10.1002/anie.200701021.

Abstract

Hold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth‐based drugs should be further evaluated for the treatment of SCV infections in vivo. ss=single‐stranded DNA, ds=duplex DNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / metabolism
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology*
  • Bismuth / chemistry*
  • Bismuth / pharmacology*
  • Cell Line
  • Cysteine / chemistry
  • DNA Helicases / antagonists & inhibitors
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Kinetics
  • Nucleic Acid Conformation / drug effects
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / pharmacology*
  • Severe acute respiratory syndrome-related coronavirus / drug effects*
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Enzyme Inhibitors
  • Organometallic Compounds
  • Adenosine Triphosphatases
  • DNA Helicases
  • Cysteine
  • Bismuth