Synthesis of substituted 1,2-dihydroquinolines and quinolines from aromatic amines and alkynes by gold(I)-catalyzed tandem hydroamination-hydroarylation under microwave-assisted conditions

Xin-Yuan Liu; Pan Ding; Jie-Sheng Huang; Chi-Ming Che

doi:10.1021/ol070814l

Synthesis of substituted 1,2-dihydroquinolines and quinolines from aromatic amines and alkynes by gold(I)-catalyzed tandem hydroamination-hydroarylation under microwave-assisted conditions

Org Lett. 2007 Jul 5;9(14):2645-8. doi: 10.1021/ol070814l. Epub 2007 Jun 12.

Authors

Xin-Yuan Liu¹, Pan Ding, Jie-Sheng Huang, Chi-Ming Che

Affiliation

¹ Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, People's Republic of China.

PMID: 17564458
DOI: 10.1021/ol070814l

Abstract

A method to efficiently prepare substituted 1,2-dihydroquinolines and quinolines by Au(I)-catalyzed tandem hydroamination-hydroarylation under microwave irradiation was developed. This method requires short reaction time (10-70 min) and has a broad substrate scope.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkynes / chemistry*
Amines / chemistry*
Catalysis
Gold / chemistry*
Gold Compounds / chemistry
Indicators and Reagents
Indoles / chemistry
Microwaves
Quinolines / chemical synthesis*

Substances

Alkynes
Amines
Gold Compounds
Indicators and Reagents
Indoles
Quinolines
indoline
Gold