Prevalence and genetic diversity of HIV type 1 subtypes A and D in women attending antenatal clinics in Uganda

AIDS Res Hum Retroviruses. 2007 May;23(5):755-60. doi: 10.1089/aid.2006.0237.A.

Abstract

To monitor the relative prevalence and evolutionary trends of HIV-1 in Uganda, we conducted a retrospective study of pregnant women over the time period 1989-2000. From a total of 300 women sampled, we defined subtypes by heteroduplex mobility assay for 230 subjects and by partial sequencing and phylogenetic analyses of the env gene for 216 subjects. Subtypes A and D were most prevalent, and there were no significant trends in relative frequencies of subtypes A (45%), D (41%), C (5%), or recombinants (9%) over the 11 years sampled. There was also no phylogenetic clustering of subtypes related to geography (clinic location) or year of collection. Mean pairwise nucleotide diversity of subtype A (pi = 0.163) and subtype D (pi =0.156) samples did not differ significantly between subtypes, nor did these levels change over the period of the study. This report suggests that among pregnant women in Uganda A and D subtypes are transmitted without geographic constraints, and are not associated with significantly different transmission rates.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Female
  • Genes, env*
  • Genetic Variation*
  • HIV Infections / epidemiology*
  • HIV Infections / virology*
  • HIV-1 / classification
  • HIV-1 / genetics*
  • Heteroduplex Analysis
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • Pregnancy
  • Pregnancy Complications, Infectious / epidemiology
  • Pregnancy Complications, Infectious / virology*
  • Prevalence
  • Retrospective Studies
  • Uganda / epidemiology

Associated data

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