Mechanical properties of femoral cortical bone following cemented hip replacement

J Orthop Res. 2007 Nov;25(11):1408-14. doi: 10.1002/jor.20388.

Abstract

Femoral bone remodeling following total hip replacement is a big concern and has never been examined mechanically. In this study, six goats underwent unilateral cemented hip hemiarthroplasty with polymethyl methacrylate (PMMA) bone cement. Nine months later animals were sacrificed, and the femoral cortical bone slices at different levels were analysed using microhardness testing and microcomputed tomography (micro-CT) scanning. Implanted femurs were compared to contralateral nonimplanted femurs. Extensive bone remodeling was demonstrated at both the proximal and middle levels, but not at the distal level. Compared with the nonimplanted side, significant decreases were found in the implanted femur in cortical bone area, bone mineral density, and cortical bone hardness at the proximal level, as well as in bone mineral density and bone hardness at the middle level. However, no significant difference was observed in either variable for the distal level. In addition, similar proximal-to-distal gradient changes were revealed both in cortical bone microhardness and bone mineral density. From the mechanical point of view, the results of the present study suggested that stress shielding is an important mechanical factor associated with bone adaptation following total hip replacement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arthroplasty, Replacement, Hip / adverse effects
  • Arthroplasty, Replacement, Hip / instrumentation*
  • Bone Cements
  • Bone Density
  • Bone Remodeling*
  • Cementation / instrumentation*
  • Cementation / methods
  • Femur / diagnostic imaging
  • Femur / metabolism
  • Femur / physiopathology*
  • Hardness
  • Hip Joint / diagnostic imaging
  • Hip Joint / metabolism
  • Hip Joint / surgery*
  • Models, Animal
  • Polymethyl Methacrylate
  • Postoperative Complications / etiology
  • Postoperative Complications / prevention & control
  • Stress, Mechanical
  • Tomography, X-Ray Computed / methods

Substances

  • Bone Cements
  • Polymethyl Methacrylate