p53 and metabolism: Inside the TIGAR

Cell. 2006 Jul 14;126(1):30-2. doi: 10.1016/j.cell.2006.06.032.

Abstract

The p53 tumor suppressor pathway coordinates DNA repair, cell-cycle arrest, apoptosis, and senescence to preserve genomic stability and prevent tumor formation. The discovery of three new target genes for p53 reveals unexpected functions for this tumor suppressor in the regulation of glucose metabolism and autophagy.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Autophagy / genetics*
  • Cell Respiration / genetics
  • Cell Survival / genetics
  • Cell Transformation, Neoplastic / genetics*
  • Energy Metabolism / genetics*
  • Glycolysis / genetics
  • Humans
  • Stress, Physiological / genetics
  • Stress, Physiological / metabolism
  • Tumor Suppressor Protein p53 / genetics*
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Tumor Suppressor Protein p53