Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas

Fertil Steril. 2006 Jul;86(1):259-62. doi: 10.1016/j.fertnstert.2005.12.049. Epub 2006 May 26.

Abstract

Catechol-O-methyl transferase (COMT) expression is higher in leiomyomas compared with paired normal myometrium. The expression of COMT in leiomyoma cells is hormonally regulated-estrogen down-regulates, whereas P and dexamethasone up-regulate, COMT expression.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dexamethasone / administration & dosage*
  • Dose-Response Relationship, Drug
  • Enzyme Activation / drug effects
  • Estradiol / administration & dosage*
  • Female
  • Gonadal Steroid Hormones / administration & dosage
  • Humans
  • Leiomyoma / enzymology*
  • Rats
  • Tumor Cells, Cultured
  • Uterine Neoplasms / enzymology*

Substances

  • Gonadal Steroid Hormones
  • Estradiol
  • Dexamethasone