Abstract
Catechol-O-methyl transferase (COMT) expression is higher in leiomyomas compared with paired normal myometrium. The expression of COMT in leiomyoma cells is hormonally regulated-estrogen down-regulates, whereas P and dexamethasone up-regulate, COMT expression.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Dexamethasone / administration & dosage*
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Dose-Response Relationship, Drug
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Enzyme Activation / drug effects
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Estradiol / administration & dosage*
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Female
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Gonadal Steroid Hormones / administration & dosage
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Humans
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Leiomyoma / enzymology*
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Rats
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Tumor Cells, Cultured
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Uterine Neoplasms / enzymology*
Substances
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Gonadal Steroid Hormones
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Estradiol
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Dexamethasone