Abstract
Angiogenesis is a major pathological component of diseases such as cancer and coronary heart disease. Although major advances have been made and encouraging clinical results obtained, safer and more effective approaches are required. The identification of new drugs from plants has a long and successful history, and certain proangiogenic and antiangiogenic plant components have been used in traditional Chinese medicine (TCM) for thousands of years. Similar to Western combination therapy, TCM uses mixtures of plant extracts, termed fufang, to maximize efficacy and minimize adverse effects or toxicity. More evidence-based research and chemical optimization of these compounds could further enhance the effectiveness of these plant-based medicines in angiotherapy.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Angiogenesis Inhibitors / isolation & purification
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Angiogenesis Inhibitors / pharmacology
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Angiogenesis Inhibitors / therapeutic use*
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Animals
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacology
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Drugs, Chinese Herbal / therapeutic use*
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Glycine max
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Humans
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Neoplasms / blood supply*
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Neoplasms / drug therapy*
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Neoplasms / pathology
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Neoplasms / prevention & control
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Neovascularization, Pathologic / prevention & control*
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Phytotherapy*
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Salvia miltiorrhiza / chemistry
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Sinomenium / chemistry
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Tripterygium / chemistry
Substances
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Angiogenesis Inhibitors
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Plant Extracts