A mixed-valent ruthenium-oxo oxalato cluster Na7[Ru4(mu3-O)4(C2O4)6] with potent anti-HIV activities

Ella Lai-Ming Wong; Raymond Wai-Yin Sun; Nancy P-Y Chung; Chen-Lung Steve Lin; Nianyong Zhu; Chi-Ming Che

doi:10.1021/ja057883k

A mixed-valent ruthenium-oxo oxalato cluster Na7[Ru4(mu3-O)4(C2O4)6] with potent anti-HIV activities

J Am Chem Soc. 2006 Apr 19;128(15):4938-9. doi: 10.1021/ja057883k.

Authors

Ella Lai-Ming Wong¹, Raymond Wai-Yin Sun, Nancy P-Y Chung, Chen-Lung Steve Lin, Nianyong Zhu, Chi-Ming Che

Affiliation

¹ Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong.

PMID: 16608312
DOI: 10.1021/ja057883k

Abstract

A structurally characterized mixed-valent tetranuclear ruthenium-oxo oxalato cluster exhibits anti-viral activities toward R5- and X4-tropic HIV-1, and possesses cytoprotective activity toward HIV-1 infected cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-HIV Agents / chemistry*
Anti-HIV Agents / pharmacology
Crystallography, X-Ray
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
HIV Reverse Transcriptase / antagonists & inhibitors
HIV-1 / physiology
Humans
In Situ Nick-End Labeling
Organometallic Compounds / chemistry
Organometallic Compounds / pharmacology
Oxalates / chemistry*
Oxalates / pharmacology
Ruthenium / chemistry*
Ruthenium / pharmacology
T-Lymphocytes / virology
Virus Replication / drug effects

Substances

Anti-HIV Agents
Organometallic Compounds
Oxalates
Ruthenium
HIV Reverse Transcriptase