Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance

Peptides. 2006 Jul;27(7):1659-67. doi: 10.1016/j.peptides.2006.02.008. Epub 2006 Apr 4.

Abstract

We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (-605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis model assessment of insulin resistance index and beta-cell function. For UTS2R, the AC haplotype (-11640A and -8515C) was associated with higher 2 h plasma glucose after a 75 g oral glucose load. Therefore, U-II and its receptor may play a role in insulin resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Base Sequence
  • Female
  • Gene Frequency
  • Genotype
  • Glucose Tolerance Test
  • Haplotypes*
  • Humans
  • Hypertension / blood
  • Hypertension / genetics*
  • Insulin Resistance*
  • Linkage Disequilibrium
  • Male
  • Models, Genetic
  • Molecular Sequence Data
  • Polymorphism, Single Nucleotide
  • Receptors, G-Protein-Coupled / genetics*
  • Urotensins / genetics*
  • Urotensins / metabolism

Substances

  • Receptors, G-Protein-Coupled
  • UTS2R protein, human
  • Urotensins
  • urotensin II