Abstract
The iron(II) complexes and with pentadentate pyridyl ligands are stable under physiological conditions and exhibit higher cytotoxicities toward a series of human carcinoma cell lines than cisplatin; can significantly increase intracellular oxidant levels, cleave supercoiled plasmid DNA in vitro without addition of a reductant and induce apoptotic cell death in human cervical epithelioid carcinoma cells (HeLa) as observed in flow cytometric studies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Cell Line, Tumor
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Chemical Phenomena
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Chemistry, Physical
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Cisplatin / pharmacology
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DNA, Superhelical / drug effects
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Drug Screening Assays, Antitumor
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Ferrous Compounds / chemical synthesis*
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Ferrous Compounds / pharmacology*
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Flow Cytometry
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HeLa Cells
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Humans
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Iron Compounds / chemical synthesis*
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Iron Compounds / pharmacology*
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Oxidants / metabolism
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Pyridines / chemical synthesis*
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Pyridines / pharmacology*
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Reactive Oxygen Species / metabolism
Substances
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Antineoplastic Agents
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DNA, Superhelical
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Ferrous Compounds
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Iron Compounds
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Oxidants
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Pyridines
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Reactive Oxygen Species
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Cisplatin