This is a pilot study of a randomized controlled trial of an individualized motivational intervention (IMI) provided by nurses to help smoking parents of sick children quit smoking. Eighty parents who brought their sick children to the hospital were entered into the study. The intervention group received an IMI from a trained nurse counselor and telephone reminders were given 1 week after the intervention. The quit rate at 1 month was 7.5% (95% CI, 0-21) in the intervention group and 2.5% (95% CI, 0-7) in the control group. Preliminary results indicated that the IMI provided by nurses seemed to be effective in helping resistant parents of sick children stop smoking. They also suggested that it was acceptable and feasible to implement such intervention in a pediatric outpatient clinic/ward in Hong Kong.