A case of multicentric reticulohistiocytosis with multiple lytic skull lesions

Clin Exp Dermatol. 2005 Sep;30(5):515-8. doi: 10.1111/j.1365-2230.2005.01843.x.

Abstract

Multicentric reticulohistiocytosis (MR) is a rare multisystemic disorder of unknown aetiology characterized by cutaneous and joint manifestations. It is associated with malignancy in up to 31% of cases. Common radiological findings are peri-articular erosions and osteolytic punched-out areas. We present a case of MR with cutaneous nodules, joint pains, and multiple lytic skull lesions--a combination that has not been described before. Osteolytic activity of proinflammatory cytokines (tumour necrosis factor-alpha and interleukin-1) may explain the peri-articular erosions often seen in MR, and the multiple lytic skull lesions seen in our patient.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Histiocytosis, Non-Langerhans-Cell / diagnostic imaging
  • Histiocytosis, Non-Langerhans-Cell / pathology*
  • Humans
  • Joint Diseases / pathology
  • Male
  • Radiography
  • Skin Diseases / pathology*
  • Skull / diagnostic imaging
  • Skull / pathology*