This study tested a model of suicidal ideation with family cohesion, expressiveness, conflicts, teacher support, teacher-student relationships and peer support as antecedents, and self-esteem and depression as mediators. Data was collected from survey questionnaires with 433 Hong Kong Chinese adolescents. The results showed that only family cohesion, conflicts, teacher support and peer support significantly predicted self-esteem and depression, with depression being a strong mediator of suicidal ideation. Implications of the findings for future research were discussed.