Abstract
Background:
Rabeprazole in combination with amoxicillin and metronidazole (RAM) has been shown to be an effective second-line treatment of Helicobacter pylori infection. The effects were compared of 7-day low-dose and high dose rabeprazole in RAM for the primary treatment of H. pylori infection in Chinese patients.
Methods:
Helicobacter pylori-positive dyspeptic patients were randomized to receive either (i) rabeprazole 10 mg, amoxicillin 1000 mg and metronidazole 400 mg (RAM-10) or (ii) high-dose rabeprazole 20 mg, amoxicillin 1000 mg and metronidazole 400 mg (RAM-20), each given twice daily for 7 days. Helicobacter pylori eradication was confirmed by (13)c-urea breath test 5 weeks after stopping medications. side-effects of treatments were documented.
Results:
A total of 120 patients were eligible for analysis. By intention-to-treat and per-protocol analysis, the eradication rates were 83% and 86% in the RAM-10 group and 75% and 76% in the RAM-20 group, respectively (P = 0.26 and P = 0.17). Both regimens were well-tolerated and compliance was >98% in both groups.
Conclusions:
Low-dose rabeprazole in combination with amoxicillin and metronidazole is an effective, economical and well-tolerated therapy for the treatment of H. pylori infection in Chinese population.
(c) 2005 Blackwell Publishing Asia Pty Ltd.
Publication types
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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2-Pyridinylmethylsulfinylbenzimidazoles
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Amoxicillin / administration & dosage
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Amoxicillin / therapeutic use*
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use*
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Benzimidazoles / administration & dosage
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Benzimidazoles / therapeutic use*
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Biopsy
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Dose-Response Relationship, Drug
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Drug Therapy, Combination
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Dyspepsia / drug therapy
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Dyspepsia / epidemiology
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Dyspepsia / etiology
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Endoscopy, Gastrointestinal
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Enzyme Inhibitors / administration & dosage
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Enzyme Inhibitors / therapeutic use*
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Female
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Helicobacter Infections / complications
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Helicobacter Infections / drug therapy*
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Helicobacter Infections / epidemiology
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Helicobacter pylori / isolation & purification
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Humans
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Male
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Metronidazole / administration & dosage
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Metronidazole / therapeutic use*
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Middle Aged
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Omeprazole / administration & dosage
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Omeprazole / analogs & derivatives*
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Omeprazole / therapeutic use
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Prevalence
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Proton-Translocating ATPases / antagonists & inhibitors
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Pyloric Antrum / microbiology
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Pyloric Antrum / pathology
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Rabeprazole
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Retrospective Studies
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Treatment Outcome
Substances
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2-Pyridinylmethylsulfinylbenzimidazoles
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Anti-Bacterial Agents
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Benzimidazoles
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Enzyme Inhibitors
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Metronidazole
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Rabeprazole
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Amoxicillin
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Proton-Translocating ATPases
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Omeprazole