Time-resolved resonance Raman observation of the 2-fluorenylnitrenium ion reaction with guanosine to form a C8 intermediate

J Am Chem Soc. 2005 Jun 15;127(23):8246-7. doi: 10.1021/ja0505651.

Abstract

Time-resolved resonance Raman spectroscopy was used to directly observe the reaction of the 2-fluorenylnitrenium ion with guanosine to produce a C8 intermediate species. Comparison of the Raman spectra with results of density functional theory calculations indicates the C8 intermediate forms two C=N conjugated bonds in ring 1 of the guanosine moiety.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Acetylaminofluorene / chemistry*
  • Carcinogens / chemistry
  • DNA Adducts / chemistry
  • DNA Damage
  • Deoxyguanosine / analogs & derivatives*
  • Guanosine / chemistry*
  • Ions
  • Spectrum Analysis, Raman

Substances

  • Carcinogens
  • DNA Adducts
  • Ions
  • Guanosine
  • 2-Acetylaminofluorene
  • Deoxyguanosine