Temporal integration of intracellular Ca2+ signaling networks in regulating gene expression by action potentials

R Douglas Fields; Philip R Lee; Jonathan E Cohen

doi:10.1016/j.ceca.2005.01.011

Temporal integration of intracellular Ca2+ signaling networks in regulating gene expression by action potentials

Cell Calcium. 2005 May;37(5):433-42. doi: 10.1016/j.ceca.2005.01.011.

Authors

R Douglas Fields¹, Philip R Lee, Jonathan E Cohen

Affiliation

¹ Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bldg. 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, MD 20892, USA. fieldsd@mail.nih.gov

PMID: 15820391
DOI: 10.1016/j.ceca.2005.01.011

Abstract

Temporal aspects of intracellular calcium signaling are particularly important in activity-dependent regulation of gene expression in neurons. This review traces calcium-dependent intracellular signaling from the membrane to the nucleus in response to action-potential firing, and considers how specific genes are regulated by specific patterns of impulse firing. Modes of calcium influx, calcium-dependent protein kinases, transcription factors, individual genes, and genomic analysis are examined, with particular emphasis on the importance of temporal aspects of calcium dynamics in regulating these processes.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Action Potentials / physiology*
Animals
Calcium / metabolism*
Calcium Signaling / physiology*
Gene Expression Regulation / physiology*
Humans
Intracellular Fluid / chemistry

Substances

Calcium