Dishevelled and Wnt signaling: is the nucleus the final frontier?

Raymond Habas; Igor B Dawid

doi:10.1186/jbiol22

Dishevelled and Wnt signaling: is the nucleus the final frontier?

J Biol. 2005;4(1):2. doi: 10.1186/jbiol22. Epub 2005 Feb 17.

Authors

Raymond Habas¹, Igor B Dawid

Affiliation

¹ Cancer Institute of New Jersey and Department of Biochemistry, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

PMID: 15720723
PMCID: PMC551522
DOI: 10.1186/jbiol22

Abstract

The phosphoprotein Dishevelled (Dsh) is an essential component of Wnt signaling pathways and transduces signals into three separate branches, the canonical, non-canonical and Ca2+ pathways. How Dsh focuses signaling into these branches remains mysterious, but a new study reveals the importance of nuclear localization of Dsh for pathway-specific activation.

Publication types

Review

MeSH terms

Adaptor Proteins, Signal Transducing
Animals
Cell Nucleus / physiology
Dishevelled Proteins
Humans
Ligands
Nuclear Envelope / physiology*
Phosphoproteins / physiology*
Protein Transport / physiology
Signal Transduction / physiology*
Wnt Proteins / genetics
Wnt Proteins / physiology*

Substances

Adaptor Proteins, Signal Transducing
Dishevelled Proteins
Ligands
Phosphoproteins
Wnt Proteins