Abstract
Pt(C/N)(phe)(1, C/N = 2-(2'-thienyl)pyridine, phe = phenylalanine) shows a high binding affinity (ca. 10(6) dm(3) mol(-1)) and selectivity towards human serum albumin (HSA) and such binding is accompanied by an enhancement of photoluminescence at 562 nm; both the protein binding affinity and cytotoxicities of [Pt(C/N)(phe)(1), Pt(C/N)(trp)(2, trp = tryptophan) and Pt(C/N)(gly)(3, gly = glycine)] are affected by the amino acid ligand with having an IC(50) of up to 1 microM against a number of carcinoma cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemistry*
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Amino Acids / metabolism*
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Cell Line, Tumor
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Cyclization
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Inhibitory Concentration 50
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Ligands
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Luminescent Agents / chemistry*
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Luminescent Agents / metabolism
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Luminescent Measurements
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Molecular Structure
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Organometallic Compounds / chemistry
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Organometallic Compounds / metabolism
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Organometallic Compounds / pharmacology
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Platinum / chemistry*
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Platinum / metabolism
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Protein Binding
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Serum Albumin / chemistry*
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Serum Albumin / metabolism
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Structure-Activity Relationship
Substances
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Amino Acids
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Ligands
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Luminescent Agents
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Organometallic Compounds
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Serum Albumin
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Platinum