Multipolymer solution-phase reactions: application to the Mitsunobu reaction

Andrew M Harned; Helen Song He; Patrick H Toy; Daniel L Flynn; Paul R Hanson

doi:10.1021/ja045188r

Multipolymer solution-phase reactions: application to the Mitsunobu reaction

J Am Chem Soc. 2005 Jan 12;127(1):52-3. doi: 10.1021/ja045188r.

Authors

Andrew M Harned¹, Helen Song He, Patrick H Toy, Daniel L Flynn, Paul R Hanson

Affiliation

¹ Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA.

PMID: 15631444
DOI: 10.1021/ja045188r

Abstract

The realization of the first polymer-on-polymer Mitsunobu reaction, in which a polymeric phosphine is used simultaneously with a polymeric azodicarboxylate, is reported. This strategy employs the use of soluble oligomers generated from ring-opening methathesis polymerization. 31P NMR analysis revealed that the two polymers were interacting to generate the Mitsunobu products. Application to several substrates, as well as comparison experiments with other polymeric reagents, is described.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Biological Factors / chemical synthesis
Chemistry, Organic / methods*
Esters / chemical synthesis*
Polymers / chemistry*
Solutions

Substances

Biological Factors
Esters
Polymers
Solutions

Grants and funding

P50 GM069663/GM/NIGMS NIH HHS/United States