Lack of evidence that DNA in antibiotic preparations is a source of antibiotic resistance genes in bacteria from animal or human sources

Susanna K P Lau; Patrick C Y Woo; Amanda P C To; Alexson T K Lau; Kwok-yung Yuen

doi:10.1128/AAC.48.8.3141-3146.2004

Lack of evidence that DNA in antibiotic preparations is a source of antibiotic resistance genes in bacteria from animal or human sources

Antimicrob Agents Chemother. 2004 Aug;48(8):3141-6. doi: 10.1128/AAC.48.8.3141-3146.2004.

Authors

Susanna K P Lau¹, Patrick C Y Woo, Amanda P C To, Alexson T K Lau, Kwok-yung Yuen

Affiliation

¹ Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

Abstract

Although DNA encoding antibiotic resistance has been discovered in antibiotic preparations, its significance for the development of antibiotic resistance in bacteria is unknown. No phylogenetic evidence was obtained for recent horizontal transfer of antibiotic resistance genes from antibiotic-producing organisms to bacteria from human or animal sources.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / analysis
Animals
Anti-Bacterial Agents / analysis*
Anti-Bacterial Agents / biosynthesis
DNA, Bacterial / analysis*
DNA-Binding Proteins / genetics
Drug Contamination*
Drug Resistance, Bacterial / genetics*
Gene Transfer, Horizontal
Genes, Bacterial*
Humans
Phylogeny
Tetracycline Resistance
Transcription Factors / genetics

Substances

Amino Acids
Anti-Bacterial Agents
DNA, Bacterial
DNA-Binding Proteins
ETV5 protein, human
Transcription Factors