A novel HLA-DRB1 allele, DRB1*0449, with a rare point mutation found in the Han population of Guangdong China

F Lv; J Gao; J Lin; Z Liu; Y Fu; B Lin; Y Liu; A Xu

doi:10.1111/j.0001-2815.2004.00215.x

A novel HLA-DRB1 allele, DRB1*0449, with a rare point mutation found in the Han population of Guangdong China

Tissue Antigens. 2004 Jun;63(6):612-3. doi: 10.1111/j.0001-2815.2004.00215.x.

Authors

F Lv¹, J Gao, J Lin, Z Liu, Y Fu, B Lin, Y Liu, A Xu

Affiliation

¹ Department of Biochemistry, College of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.

PMID: 15140046
DOI: 10.1111/j.0001-2815.2004.00215.x

Abstract

Anovel HLA-DRB1 allele, DRB1*0449, has been identified in the Han population of Guangdong Province of China. Compared with DRB1*0406, it has only one single-nucleotide mutation from G to A at position 18 of exon 2, which causes a change in the protein sequence from valine to isoleucine at codon 11 of DR beta chain.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Base Sequence
China
HLA-DR Antigens / genetics*
HLA-DRB1 Chains
Humans
Molecular Sequence Data
Sequence Alignment

Substances

HLA-DR Antigens
HLA-DRB1 Chains
HLA-DRB1*04:49 antigen