Multiplicity of Ca2+ messengers and Ca2+ stores: a perspective from cyclic ADP-ribose and NAADP

Curr Mol Med. 2004 May;4(3):227-37. doi: 10.2174/1566524043360753.

Abstract

It is generally believed that multiple Ca2+ stores are present in cells, a notion that has now been made substantive by the discovery of multiple Ca2+ mobilizing messengers. Cyclic ADP-ribose (cADPR) and nicotinic acid dinucleotide phosphate (NAADP) are two such messengers that are derived from NAD and NADP, respectively. A wide variety of cells, from plants to mammals, including human, have been shown to be responsive to these two novel Ca2+ messengers. Not only are their structures and mechanisms of action different, their targeted Ca2+ stores are also distinct and separable. This article explores the implications of the multiplicity of Ca2+ stores in cellular signaling. Special emphasis will be put on the recent progress in the understanding of the physiological functions of NAADP.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Catalysis
  • Cyclic ADP-Ribose / metabolism*
  • Humans
  • NADP / analogs & derivatives
  • NADP / metabolism*

Substances

  • Cyclic ADP-Ribose
  • NADP
  • NAADP
  • Calcium