Clinical experience with minocycline and rifampin-impregnated central venous catheters in bone marrow transplantation recipients: efficacy and low risk of developing staphylococcal resistance

Infect Control Hosp Epidemiol. 2003 Dec;24(12):961-3. doi: 10.1086/502167.

Abstract

In this retrospective evaluation of the 4-year clinical use of minocycline and rifampin-impregnated catheters in bone marrow transplantation (BMT) patients, we report low risk of development of staphylococcal resistance to the antibiotics coating the catheters and efficacy in preventing primary staphylococcal bloodstream infections.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / pharmacology
  • Antibiotics, Antitubercular / administration & dosage*
  • Antibiotics, Antitubercular / pharmacology
  • Bone Marrow Transplantation / instrumentation
  • Catheterization, Central Venous / adverse effects
  • Catheterization, Central Venous / instrumentation*
  • Catheters, Indwelling / microbiology*
  • Cohort Studies
  • Cross Infection / etiology
  • Cross Infection / prevention & control*
  • Drug Delivery Systems*
  • Drug Resistance
  • Female
  • Humans
  • Infection Control / methods
  • Leukemia / surgery
  • Male
  • Middle Aged
  • Minocycline / administration & dosage*
  • Minocycline / pharmacology
  • Neutropenia / microbiology
  • Neutropenia / prevention & control*
  • Rifampin / administration & dosage*
  • Rifampin / pharmacology
  • Staphylococcal Infections / etiology
  • Staphylococcal Infections / prevention & control*
  • Texas

Substances

  • Anti-Bacterial Agents
  • Antibiotics, Antitubercular
  • Minocycline
  • Rifampin