Isochromosome 14q and leukemia with dysplastic features

Cancer Genet Cytogenet. 1992 Nov;64(1):97-8. doi: 10.1016/0165-4608(92)90333-4.

Abstract

We report a case of chronic myelomonocytic leukemia (CMMoL) with unusual features and an isochromosome 14q as the sole abnormality. A review of the literature suggests that isochromosome 14q (or trisomy 14) is a marker of leukemia with dysplastic features.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Anemia, Refractory, with Excess of Blasts / complications
  • Cell Transformation, Neoplastic
  • Chromosomes, Human, Pair 14*
  • Gene Expression Regulation, Leukemic
  • Humans
  • Hypergammaglobulinemia / complications
  • Leukemia, Myelomonocytic, Chronic / etiology
  • Leukemia, Myelomonocytic, Chronic / genetics*
  • Male
  • Middle Aged
  • Red-Cell Aplasia, Pure / complications
  • Trisomy*