Translocation (12;17)(p11-12;q11-12): a recurrent primary rearrangement in acute leukemia

Cancer Genet Cytogenet. 1992 Nov;64(1):27-9. doi: 10.1016/0165-4608(92)90317-2.

Abstract

We identified two patients with acute leukemia in relapse (one lymphoblastic and the other with evidence of mixed lymphoid-myeloid differentiation) with t(12;17)(p12;q11) as the primary karyotypic abnormality. There are six previously reported cases of acute leukemia with an identical or similar translocation. To our knowledge, t(12;17) has not been reported in other forms of neoplasia. A review of these cases suggests that t(12;17) carries a poor prognosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Antigens, CD / analysis
  • Antigens, Neoplasm / analysis
  • Chromosomes, Human, Pair 12*
  • Chromosomes, Human, Pair 17*
  • Gene Rearrangement
  • Humans
  • Immunophenotyping
  • Karyotyping
  • Leukemia, Lymphoid / genetics*
  • Leukemia, Lymphoid / pathology
  • Leukemia, Myeloid, Acute / genetics*
  • Male
  • Prognosis
  • Translocation, Genetic*

Substances

  • Antigens, CD
  • Antigens, Neoplasm