Infants born to mothers with severe acute respiratory syndrome

Chi C Shek; Pak C Ng; Genevieve P G Fung; Frankie W T Cheng; Paul K S Chan; Malik J S Peiris; Kim H Lee; Shell F Wong; Hon M Cheung; Albert M Li; Ellis K L Hon; Chung K Yeung; Chun B Chow; John S Tam; Man C Chiu; Tai F Fok

doi:10.1542/peds.112.4.e254

Infants born to mothers with severe acute respiratory syndrome

Pediatrics. 2003 Oct;112(4):e254. doi: 10.1542/peds.112.4.e254.

Authors

Chi C Shek¹, Pak C Ng, Genevieve P G Fung, Frankie W T Cheng, Paul K S Chan, Malik J S Peiris, Kim H Lee, Shell F Wong, Hon M Cheung, Albert M Li, Ellis K L Hon, Chung K Yeung, Chun B Chow, John S Tam, Man C Chiu, Tai F Fok

Affiliation

¹ Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Lai Chi Kok, New Territories, Hong Kong.

PMID: 14523207
DOI: 10.1542/peds.112.4.e254

Abstract

Severe acute respiratory syndrome (SARS) is a newly discovered infectious disease caused by a novel coronavirus. During the community outbreak in Hong Kong, 5 liveborn infants were born to pregnant women with SARS. A systematic search for perinatal transmission of the SARS-associated coronavirus, including serial reverse transcriptase-polymerase chain reaction assays, viral cultures, and paired serologic titers, failed to detect the virus in any of the infants. In addition, none of the infants developed clinical, radiologic, hematologic, or biochemical evidence suggestive of SARS. One preterm infant developed jejunal perforation and another developed necrotizing enterocolitis with ileal perforation shortly after birth. This case series is the first report to describe the clinical course of the first cohort of liveborn infants born to pregnant women with SARS.

Publication types

Case Reports

MeSH terms

Adult
Anti-Inflammatory Agents / adverse effects
Anti-Inflammatory Agents / therapeutic use
Antiviral Agents / adverse effects
Antiviral Agents / therapeutic use
Cesarean Section
Cohort Studies
Disease Outbreaks
Enterocolitis, Necrotizing / etiology
Female
Fetal Growth Retardation / etiology
Hong Kong / epidemiology
Humans
Ileal Diseases / etiology
Infant, Newborn
Infant, Premature
Infectious Disease Transmission, Vertical*
Intestinal Perforation / etiology
Jejunal Diseases / etiology
Male
Methylprednisolone / adverse effects
Methylprednisolone / therapeutic use
Pregnancy
Pregnancy Complications, Infectious / drug therapy
Pregnancy Complications, Infectious / epidemiology
Pregnancy Complications, Infectious / virology*
Respiratory Distress Syndrome, Newborn / complications
Ribavirin / adverse effects
Ribavirin / therapeutic use
Severe Acute Respiratory Syndrome / drug therapy
Severe Acute Respiratory Syndrome / epidemiology
Severe Acute Respiratory Syndrome / transmission*
Severe acute respiratory syndrome-related coronavirus / isolation & purification

Substances

Anti-Inflammatory Agents
Antiviral Agents
Ribavirin
Methylprednisolone