Fragile X positivity in Chinese children with autistic spectrum disorder

Pediatr Neurol. 1992 Jul-Aug;8(4):272-4. doi: 10.1016/0887-8994(92)90364-5.

Abstract

Chromosome analysis was performed in 105 Chinese children (96 boys, 9 girls) with autistic spectrum disorder to assess fragile X positivity. Seventy percent of these autistic children were mentally retarded. None of the children in the infantile autism group (N = 75) had fragile X positivity. Two boys in the autistic condition group (N = 30) had clinical features and chromosomal positivity for fragile X syndrome. The low (2%) prevalence rate of fragile X positivity in children with different degrees of expressivity of autistic features may be related to other factors rather than to pure autistic characteristics per se.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autistic Disorder / diagnosis
  • Autistic Disorder / genetics*
  • Child
  • Child, Preschool
  • Female
  • Fragile X Syndrome / diagnosis
  • Fragile X Syndrome / genetics*
  • Gene Frequency / genetics*
  • Genetic Markers / genetics
  • Hong Kong
  • Humans
  • Infant
  • Intellectual Disability / diagnosis
  • Intellectual Disability / genetics
  • Male

Substances

  • Genetic Markers