Self-assembled multivalent vancomycin on cell surfaces against vancomycin-resistant enterococci (VRE)

Bengang Xing; Pak Leung Ho; Chun-Wing Yu; Kin-Hung Chow; Hongwei Gu; Bing Xu

doi:10.1039/b305886g

Self-assembled multivalent vancomycin on cell surfaces against vancomycin-resistant enterococci (VRE)

Chem Commun (Camb). 2003 Sep 7:(17):2224-5. doi: 10.1039/b305886g.

Authors

Bengang Xing¹, Pak Leung Ho, Chun-Wing Yu, Kin-Hung Chow, Hongwei Gu, Bing Xu

Affiliation

¹ Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.

PMID: 13678212
DOI: 10.1039/b305886g

Abstract

A vancomycin (Van) derivative self-assembles in a phosphate buffer as a divalent Van and on cell surfaces as a multivalent Van, which offers potent activity against VRE.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Binding, Competitive
Dimerization
Enterococcus / drug effects*
Microbial Sensitivity Tests
Vancomycin / analogs & derivatives*
Vancomycin / chemistry
Vancomycin / pharmacology*
Vancomycin Resistance*

Substances

Anti-Bacterial Agents
Vancomycin