Anisodamine antagonizes acetylcholine-induced inhibition of adrenergic neurotransmission in the canine saphenous vein

Chin Med Sci J. 1992 Mar;7(1):32-5.

Abstract

The effect of anisodamine, an alkaloid structurally related to atropine and isolated from a Chinese herb, on adrenergic neurotransmission was studied using isolated canine saphenous veins. Helical strips of vein were incubated in modified physiological salt solution containing L-(7- 3H)-norepinephrine (3 x 10(-7) mol/L) for two hours and then mounted for isometric tension recording and superfusion. Increases in isometric tension and efflux of total tritiated compounds and 3H-norepinephrine evoked by electrical stimulation were inhibited by acetylcholine (10(-6) mol/L). This effect of acetylcholine was antagonized to comparable levels by anisodamine (10(-6) mol/L) or atropine (10(-6) mol/L). The results demonstrate that anisodamine blocks prejunctional muscarinic receptors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetylcholine / antagonists & inhibitors*
  • Animals
  • Atropine / pharmacology
  • Dogs
  • In Vitro Techniques
  • Muscle Contraction / drug effects
  • Muscle, Smooth, Vascular / drug effects
  • Muscle, Smooth, Vascular / innervation*
  • Norepinephrine / pharmacology
  • Parasympatholytics / pharmacology*
  • Receptors, Muscarinic / drug effects
  • Saphenous Vein
  • Solanaceous Alkaloids / pharmacology*
  • Synaptic Transmission / drug effects*

Substances

  • Parasympatholytics
  • Receptors, Muscarinic
  • Solanaceous Alkaloids
  • anisodamine
  • Atropine
  • Acetylcholine
  • Norepinephrine